Anterior cruciate ligament (ACL) tears may offer researchers opportunities to study potential interventions to prevent the initiation of heightened osteoarthritis (OA) risk at the time of injury, a recent study suggests. To further explore the feasibility of randomized controlled trials (RCT) for Early Arthritis Therapies (EARTH) involving ACL cohort tears, the cross-sectional study reportedly sought to test the hypothesis that adequate sample sizes of ACL-injured subjects to support RCT of early intervention strategies can be achieved.
According to researchers, 307 ACL-injured patients were entered into the database from 3-month collection periods at 7 clinical sites.A total of 65 subjects aged 18 years to 30 years old passed the study’s inclusion/exclusion criteria.
The study’s results suggest that 93% participants were willing to participant in an RCT. Researchers add that the study indicates adequate sample sizes to perform RCT of early intervention strategies in ACL-injured cohorts, comprised of health young adults aged 18 years to 30 years old without prior injuries, can be achieved within a year to 2 years through recruitment at 5 to 7 orthopaedic sports medicine practices.
The release notes that the continued development of ACL-tear cohorts may ultimately help build the clinical base to critically evaluate new diagnostic and therapeutic strategies to help prevent OA.
Source: PubMed
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